| Bioactivity | PROTAC Hemagglutinin Degrader-1 (Compound V3) is a potent PROTAC influenza hemagglutinin (HA) degrader with a median degradation concentration of 1.44 μM. PROTAC Hemagglutinin Degrader-1 shows broad-spectrum anti-influenza virus activity[1]. |
| In Vivo | PROTAC Hemagglutinin Degrader-1 (0-20 mg/kg; i.v.; daily for 5 days) protects mice against influenza A virus-induced toxic effects[1].PROTAC Hemagglutinin Degrader-1 displays a moderate oral bioavailability of approximately 6.8%[1]. |
| Name | PROTAC Hemagglutinin Degrader-1 |
| Formula | C61H93N5O9S |
| Molar Mass | 1072.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li H, et al. Discovery of Pentacyclic Triterpenoid PROTACs as a Class of Effective Hemagglutinin Protein Degraders. J Med Chem. 2022 May 26;65(10):7154-7169. |
PROTAC Hemagglutinin Degrader-1
CAS: F: C61H93N5O9S W: 1072.48
PROTAC Hemagglutinin Degrader-1 (Compound V3) is a potent PROTAC influenza hemagglutinin (HA) degrader with a median deg
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